Rapid, Near-Patient Monitoring of Heparin in Children

Multifunctional Platform for Viscoelastic aPTT and Fluorometric aFXa Whole Blood Testing in Near-Patient Settings for Pediatric Patients on
Heparin Therapy

Heparin monitoring tests for anti-Factor Xa activity (aFXa) and activated partial thromboplastin time (aPTT) assays require frequent measurements with large volumes of blood, which may lead to iatrogenic anemia in neonatal and pediatric patients.

In this study, we describe two novel approaches for aFXa and aPTT performed on the multifunctional DMF cartridge using microliter reaction volumes and whole blood sample input, allowing frequent testing in neonatal and pediatric patients susceptible to iatrogenic anemia.