Novel application of digital microfluidics for the detection of biotinidase deficiency in newborns

To demonstrate that different assays can be performed on the same digital microfluidic cartridge, this study demonstrated feasibility of performing an enzyme assay for biotinidase deficiency on the same cartridge used for detecting enzyme activity of lysosomal storage disorders.

Authors: Carrie Graham, Ramakrishna S. Sista, Jairus Kleinert, Ning Wu, Allen Eckhardt, Deeksha Bali, David S. Millington, and Vamsee K. Pamula

Clin Biochem. 2013 December; 46(18): 1889–1891. doi:10.1016/j.clinbiochem.2013.09.003.