Digital Microfluidic Platform for Multiplexing Enzyme Assays: Implications for Lysosomal Storage Disease Screening in Newborns

This study was one of the first published that demonstrated feasibility of using the digital microfluidic fluorimetric assays to test enzyme activity of lysosomal storage disorders (specifically Pompe and Fabry).

Authors: Ramakrishna S. Sista, Allen E. Eckhardt, Tong Wang, Carrie Graham, Jeremy L. Rouse, Scott M. Norton, Vijay Srinivasan, Michael G. Pollack, Adviye A. Tolun, Deeksha Bali, David S. Millington, and Vamsee K. Pamula

Clinical Chemistry 57:10 1444–1451 (2011)

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